污水处理厂中四环素类抗生素残留及其抗性基因污染 特征研究进展

四环素类抗生素以其突出的抗菌性能和较低的副作用而被广泛用于细菌感染疾病的治疗和控制, 污水处理系统作为环境中四环素类抗生素及其抗性基因的一个重要污染点源, 已引起广泛关注。尽管如此, 目前关于四环素类抗生素在污水处理过程中的降解行为及影响因子, 及其对降解微生物抗药性的选择性效应方面的研究还较少。在分析总结国内外四环素类抗生素污染现状基础上, 对污水处理过程中四环素类抗生素的去除行为及影响因素等进行分析, 探讨了其抗性基因在污水处理过程中的污染特征, 同时分析了四环素类抗生素对其抗性基因的诱导、演变和传播的影响, 并对今后的研究发展方向进行了展望, 以期为从污水处理系统达到控制和去除四环素类抗生素及其抗性基因提供方向和依据。

Pollution characteristics of tetracycline residues and tetracycline resistance genes in sewage treatment plants:A review

Tetracycline antibiotics have been widely administered to treat and control diseases due to their effective antimicrobial actions and the lack of major side effects. The sewage treatment plants have attracted much attention as one of the main point-sources of pollution with respect to tetracycline antibiotics and tetracycline resistance genes. However, only few studies were focusing on the degradation behavior of tetracycline antibiotics during sewage treatment process and the pressure selection on their corresponding resistance genes. Based on the summary of pollution situati on of tetracycline antibiotics, their removal behavior and relevant influencing factors during sewage treatment process were analyzed. The pollution characteristics of tetracycline resistance genes were investigated. In addition, the effects of tetracycline antibiotics on the induction, evolution and spread of tetracycline resistance genes were discussed. Finally, the future research directions in this area were suggested. The aim of this review is to provide the direction and evidence for the removal of tetracycline antibiotics and tetracycline resistance genes in sewage treatment systems.