2-氨基-6-甲基苯并噻唑的合成改进

采用冰醋酸作催化剂兼溶剂合成2-氨基-6-甲基苯并噻唑(AMEBT)的改进工艺。探讨了物料比、反应温度和时间对反应收率的影响。结果表明,较佳反应条件为:对-甲苯胺∶硫氰酸铵∶溴素=1.0∶1.2∶1.1(摩尔比),反应温度为16~20℃,硫氰酸铵与对-甲苯胺的反应时间、溴素的滴加及加入后的反应时间依次为1.5,3.0,1.0 h,总收率为84%。该方法具有操作简单、反应条件温和、易纯化、原料消耗少、收率高的优点。

Improvement in synthesis of 2-amino-6-methylbenzothiazole

The improved procedure of the synthesis of 2-amino6-methylbenzothiazole using acetic acid as catalyst and solvent was reported in this paper.The effects of the mole ratio of materials,reaction temperature and time on yield were discussed.We could receive the best reaction condition:p-toluidine ∶ammonium thiocanate ∶bromine is 1.0 ∶1.2 ∶1.1(mole ratio),the temperature is 16～20 ℃,the reaction time of p-toluidine with ammonium thiocanate is 1.5 h,the dropping time of bromine is 3.0 h and the following reaction time is 1.0 h,the total yield is 84%.Compared to the previous methods,this new method has the advantages of simple procedure,mild conditions,easy purification,less materials consume and good yield.