| 一锅法合成(E)-红霉素A肟的新工艺 |
| |
| 引用本文： | 许青青,周兆良,姜华.一锅法合成(E)-红霉素A肟的新工艺[J].化学试剂,2009,31(7). |
| |
| 作者姓名： | 许青青 周兆良 姜华 |
| |
| 作者单位： | 浙江工业大学,浙西分校化学与制药工程系,浙江,衢州,324000 |
| |
| 摘 要： | 硫氰酸红霉素、三乙胺、盐酸羟胺"一锅法"合成红霉素A肟硫氰酸盐,再用NaOH溶液中和、乙醇/水体系莆结晶得标题化合物.产品用熔点测定、元素分析、IR和1HNMR进行了表征.探索了反应条件对产品收率和纯度的影响.在优化条件下,产品的总收率为85.6%,纯度>97.8%(HPLC).与其他工艺相比,生产成本町明显降低.
|
| 关 键 词： | 硫氰酸红霉素 (E)-红霉素A肟 合成 |
One pot synthesis of(E)-erythromycin A oxime |
| |
| XU Qing-qing,ZHOU Zhao-liang,JIANG Hua.One pot synthesis of(E)-erythromycin A oxime[J].Chemical Reagents,2009,31(7). |
| |
| Authors: | XU Qing-qing ZHOU Zhao-liang JIANG Hua |
| |
| Affiliation: | Chemistry and Pharmaceutical Department of West Branch of Zhejiang Industry University;Quzhou 324000;China |
| |
| Abstract: | (E)-erythromycin A oxime was synthesized in one pot by the oximation reaction using erythromycin thiocyanate,triethylamine and hydroxyamine hydrochloride as the starting materials,followed by neutralization with NaOH solution and recrystallization in the ethanol/water system.The product structure was confirmed by melting point determination,elementary analysis.IR spectrometry and 1HNMR spectrometry.Effects of reaction conditions on the product yield and purity were investigated.The product yield reached 85.... |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
