| 4-甲基-5-乙烯基尼古丁腈的合成 |
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| 引用本文： | 冯启国,张杨,任凤霞,杨郁,刘津,赵毅民.4-甲基-5-乙烯基尼古丁腈的合成[J].化学试剂,2011(7):655-656,672. |
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| 作者姓名： | 冯启国 张杨 任凤霞 杨郁 刘津 赵毅民 |
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| 作者单位： | 军事医学科学院毒物药物研究所; |
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| 基金项目： | 综合性新药研究开发技术大平台资助项目(2009ZX09301-002) |
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| 摘 要： | 以2-乙酰丁酸内酯和氰乙酰胺为原料,经缩合、氯代、催化氢化以及消除4步反应,合成了标题化合物,总收率59.9%.产物结构经核磁共振氢谱和质谱确认.
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| 关 键 词： | 氰乙酰胺 4-甲基-5-乙烯基尼古丁腈 合成 |
Synthesis of 4-methyl-5-vinylnicotinonitrile |
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| FENG Qi-guo,ZHANG Yang,REN Feng-xia,YANG Yu,LIU Jin,ZHAO Yi-min.Synthesis of 4-methyl-5-vinylnicotinonitrile[J].Chemical Reagents,2011(7):655-656,672. |
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| Authors: | FENG Qi-guo ZHANG Yang REN Feng-xia YANG Yu LIU Jin ZHAO Yi-min |
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| Affiliation: | FENG Qi-guo,ZHANG Yang,REN Feng-xia,YANG Yu,LIU Jin,ZHAO Yi-min*(The Academy of Military Medical Science,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China) |
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| Abstract: | 4-Methyl-5-vinylnicotinonitrile was synthesized from 2-acetylbutyrolactone and cyanoacetamide in four steps with an overall yield of 59.9%.The structure of the target compound was confirmed by 1HNMR and MS analyses. |
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| Keywords: | cyanoacetamide 4-methyl-5-vinylnicotinonitrile synthesis |
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