| 二(三)苯基锗β-吲哚基羧酸酯的合成和性质 |
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| 引用本文： | 尹汉东,张如芬,王勇,马春林.二(三)苯基锗β-吲哚基羧酸酯的合成和性质[J].化学试剂,2002,24(4):219-220,249. |
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| 作者姓名： | 尹汉东 张如芬 王勇 马春林 |
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| 作者单位： | 聊城师范学校化学系,聊城,252059 |
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| 基金项目： | 教育部骨干教师基金及山东省自然科学基金资助项目 (No.Z2 0 0 1 B0 2 ) |
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| 摘 要： | 通过二（三）苯基氯化锗β－吲哚基羧酸酯反应合成了9种新的二（三）苯基锗β－吲哚基羧酸酯。利用元素分析、红外光谱、核磁共振氢谱表征了这些化合物的结构，红外光谱测试表明，所有化合物中羧基是以单齿形式与锗原子配位。生物活性测试结果表明，该类化合物对MCF－7癌细胞具有较高的体外抑制活性。
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| 关 键 词： | 二（三）苯基锗β－吲哚基羧酸酯 合成 性质 苯基锗 β－吲哚羧酸酯 生物活性 MCF－7癌细胞 体外抑制活性 |
| 文章编号： | 0258-3283(2002)04-0219-02 |
Synthesis and properties of di-or triphenylgermanium in dolylcarboxylates |
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| Yin Handong ,Zhang Rufen,Wang Yong,Ma Chunlin.Synthesis and properties of di-or triphenylgermanium in dolylcarboxylates[J].Chemical Reagents,2002,24(4):219-220,249. |
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| Authors: | Yin Handong Zhang Rufen Wang Yong Ma Chunlin |
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| Affiliation: | Yin Handong *,Zhang Rufen,Wang Yong,Ma Chunlin |
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| Abstract: | Nine new di or triphenylgermanium indolylcarboxylates were synthesized by the reaction of di or triphenylgermanium chloride with indolylcarboxylates. Their structures were characterized by elementary analysis, IR and 1HNMR. The IR spectra showed that these carboxyl groups are monodentate ligands in compounds 1~9. In vitro rest, these compounds showed high antitumor activities against human tumor cell line MCF 7. |
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| Keywords: | di ortriphenylgermanium indolylcarboxylates synthesis biological activity |
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