| 碘海醇的合成工艺优化 |
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| 引用本文： | 孙跃军,郑国钧.碘海醇的合成工艺优化[J].化学试剂,2012,34(2):185-186,189. |
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| 作者姓名： | 孙跃军 郑国钧 |
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| 作者单位： | 北京化工大学生命科学与技术学院,北京,100029 |
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| 摘 要： | 以5-硝基间苯二甲酸为原料,依次通过酯化、还原、碘代、乙酰化等反应得到中间体5-(乙酰氨基)-N,N’-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺,缩水甘油与上述化合物缩合得到碘海醇。目标产物及相关杂质均符合药典要求,路线操作简便,适宜工业化。
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| 关 键 词： | 碘海醇 缩水甘油 合成 |
Optimization of synthetic process for iohexol |
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| SUN Yue-jun
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ZHENG Guo-jun.Optimization of synthetic process for iohexol[J].Chemical Reagents,2012,34(2):185-186,189. |
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| Authors: | SUN Yue-jun ZHENG Guo-jun |
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| Affiliation: | *(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China) |
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| Abstract: | Starting with 5-nitroisophthalic acid,the intermediate compound 5-(acetamido)-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiono-1,3-benzenedicarboxamide was obtained by several steps reaction such as esterification,reduction,iodination,acylation successively.And then,iohexol was obtained by coupling glycidol with the above-mentioned compound.The target product and related impurities based onstandard of Pharmacopoeia.The process is simple and suitable for industrial production. |
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| Keywords: | iohexol glycido synthesis |
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