| 1,6-二羟基-2-萘甲酸的合成研究 |
| |
| 引用本文： | 韩科展,张梦辉,周志旭,赵春深.1,6-二羟基-2-萘甲酸的合成研究[J].化学试剂,2017,39(7). |
| |
| 作者姓名： | 韩科展 张梦辉 周志旭 赵春深 |
| |
| 作者单位： | 1. 贵州大学化学与化工学院,贵州贵阳550003;贵州大学药学院贵州省合成药物工程实验室,贵州贵阳550003;2. 贵州大学药学院贵州省合成药物工程实验室,贵州贵阳,550003 |
| |
| 基金项目： | 贵州省科技厅社发公关项目，贵州大学引进人才科研项目(贵大人基合字 |
| |
| 摘 要： | 标题化合物是合成新型内分泌治疗剂的重要中间体,而其合成方法未见文献报道。以6-甲氧基-1-萘满酮为起始原料,经取代、氧化和水解3步反应得到目标产物,其结构经MS、~1HNMR、~(13)CNMR和IR确证。该路线原料廉价易得、操作简单、后处理方便,总收率达69.5%,适合工业化生产。
|
| 关 键 词： | 1 6-二羟基-2-萘甲酸 6-甲氧基-1-萘满酮 合成 |
Synthesis of 1, 6-Dihydroxy-2-naphthoic Acid |
| |
| HAN Ke-zhan,ZHANG Meng-hui,ZHOU Zhi-xu,ZHAO Chun-shen.Synthesis of 1, 6-Dihydroxy-2-naphthoic Acid[J].Chemical Reagents,2017,39(7). |
| |
| Authors: | HAN Ke-zhan ZHANG Meng-hui ZHOU Zhi-xu ZHAO Chun-shen |
| |
| Abstract: | 1,6-Dihydroxy-2-naphthoic acid is an important intermediate for the synthesis of new endocrine the rapy medicine.ln this work,6-methoxy-l-tetralone was used as the starting material.The target product was obtained by three steps of substitution,oxidation and hydrolysis.The structures were confirmed by MS,1HNMR,13CNMR and IR.The raw material of this route is cheap and easy to obtain,and the optimized process is simple in operation,short in reaction time and easy to purify.The total yield reaches 69.5％,which is suitable for industrial production. |
| |
| Keywords: | 1 6-dihydroxy-2-naphthoic acid 6-methoxy-1-tetralone synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
