含羟基功能基1,3,4-噻二唑硫醚大环化合物的合成研究

报道以2,5-二巯基-1,3,4-噻二唑、2-羟基-1,3-二氯丙烷和氮氧化钾为原料,成功合成了新型含羟基功能基1,3,4-噻二唑硫醚大环化合物.并探讨了合成目标大环化合物的最佳合成条件:以无水乙醇做溶剂,在强碱和高度稀释条件下原料投料比(摩尔比)为1:1:4,于75～80℃条件下反应18h的产率达到45.3%.产品通...

Study on Synthesis of 1,3,4-Thiadiazol Cyclic Polyether Macrocyclic Compound Bearing Hydroxyl Functional Group

The novel 1,3,4-thiadiazol cyclic polyether compound bearing hydroxyl functional group was synthesized from 2,5-dimercapto-1,3,4-thiadiazole,1,3-dichloro-2-propanol and KOH.The favorable reaction conditions of synthesizing the title macrocyclic compound were found as follows: in highly diluted and caustic alkali solution,the reaction time was about 18h,the reaction temperature was 75～80℃,the mole ratio of 2,5-dimercapto-1,3,4-thiadiazole,1,3-dichloro-2-propanol to KOH was 1∶1∶4 in anhydrous ethanol.The yield of the title of compound was 45.3%.The macrocyclic compound was characterized by elemental analysis,1H NM R,IR and MS.