| 四种单萜类查尔酮的合成 |
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| 引用本文： | 陈兵兵,解鹤,康建.四种单萜类查尔酮的合成[J].化学世界,2020,61(1):57-60. |
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| 作者姓名： | 陈兵兵 解鹤 康建 |
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| 作者单位： | 宁夏理工学院-文理学院,宁夏石嘴山753000;宁夏理工学院-文理学院,宁夏石嘴山753000;宁夏理工学院-文理学院,宁夏石嘴山753000 |
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| 基金项目： | 宁夏高等学校科学技术研究;宁夏青年教师教学改革 |
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| 摘 要： | 以2, 4, 6-三羟基苯乙酮和柠檬醛为起始原料经过环化、羟醛缩合和催化加氢合成四种单萜类查尔酮;关键步骤2, 4, 6-三羟基苯乙酮和柠檬醛是在吡啶的催化下经过电子环化、质子迁移及Diels-Alder反应合成天然产物desbenzylidenerubramin (1),中间体1合成一种天然产物产物rubraine (2~5),其结构经~1H NMR和HREIMS表征。
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| 关 键 词： | 合成 desbenzylidenerubramin 单萜类查尔酮 |
Synthesis of Four Monoterpene Chalcone |
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| Chen Bingbing,Jie He,Kang Jian.Synthesis of Four Monoterpene Chalcone[J].Chemical World,2020,61(1):57-60. |
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| Authors: | Chen Bingbing Jie He Kang Jian |
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| Affiliation: | (CNingxia Institute of Science and Technology-Wenli College,Shizuishan,Ningxia 753000,China}) |
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| Abstract: | Synthesis of four monoterpene chalcone was achieved through cyclization, aldol condensation and catalytic addition starting from 2, 4, 6-trihydroxyacetophenone and citral. The key strategies of the synthesis of desbenzylidenerubramin(1) involved the pyridine catalyzed cyclization, H-shift and Diels-Alder reaction. The intermediate 1 was used for the synthesis of natural product of rubraine(2~5) and unnatural derivatives and their structures were characterized by ~1H NMR and HREIMS. |
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| Keywords: | synthesis desbenzylidenerubramin monoterpene chalcone |
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