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| [EMIM]BF_4离子液体催化合成镇痛消炎药酮咯酸中间体2-苯甲酰吡咯 | |
| 引用本文： | 项东升,朱驯,朱其军,陆鸿飞.[EMIM]BF_4离子液体催化合成镇痛消炎药酮咯酸中间体2-苯甲酰吡咯[J].化学世界,2013,54(5):301-304. |
| 作者姓名： | 项东升 朱驯 朱其军 陆鸿飞 |
| 作者单位： | 1. 盐城纺织职业技术学院化学工程系,江苏盐城,224005 2. 盐城纺织职业技术学院化学工程系,江苏盐城224005;南京理工大学化工学院,江苏南京210094 3. 盐城格瑞茵化工有限公司,江苏盐城,224400 4. 南京理工大学化工学院,江苏南京210094;江苏科技大学材料科学与工程学院,江苏镇江212003 |
| 基金项目： | 江苏省高校科研成果产业化推进项目，江苏省第二批科技型企业技术创新资金 |
| 摘 要： | 制备了离子液体EMIM]BF4,并用于催化合成镇痛消炎药酮咯酸中间体2-苯甲酰吡咯。考察离子液体EMIM]BF4的催化活性及重复使用性能,研究了原料配比、反应温度和反应时间等工艺条件的影响。较佳工艺条件为:反应物料配比n(EMIM]BF4)∶n(苯甲酰氯)∶n(吡咯)=1.0∶1.0∶1.2,反应温度50℃,反应时间8h。在此条件下,2-苯甲酰吡咯收率达86%以上,纯度达99%。其离子液体可重复利用,经5次利用后产物收率仍在80%以上,并可避免使用有机溶剂。 |
| 关 键 词： | [EMIM]BF4离子液体 2-苯甲酰吡咯 催化 合成 |
Synthesis of Analgesic Ketorolac Intermediate 2-Benzoylpyrrole Catalyzed by [EMIM] BF4 Ionic Liquid |
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| XIANG Dong-sheng,ZHU Xun,ZHU Qi-jun,LU Hong-fei.Synthesis of Analgesic Ketorolac Intermediate 2-Benzoylpyrrole Catalyzed by [EMIM] BF4 Ionic Liquid[J].Chemical World,2013,54(5):301-304. | |
| Authors: | XIANG Dong-sheng ZHU Xun ZHU Qi-jun LU Hong-fei |
| Affiliation: | 2,4(1.Department of Chemical Engineering,Yancheng Institute of Textile Vocational Technology,Jingsu Yancheng 224005,China; 2.Department of Chemical Engineering,Nanjing University of Science &Technology,Jingsu Nanjing 210094,China; 3.Yancheng Green Chemicals Co.,Ltd.,Jingsu Yancheng 224400,China; 4.School of Material Science and Engineering,Jiangsu University of Science and Technology,Jiansun Zhenjiang 212003,China) |
| Abstract: | EMIM]BF4 ionic liquid was synthesized and used to catalyze analgesic ketorolac intermediate 2-benzoylpyrrole.The catalytic activity and the reusability of ionic liquid EMIM]BF4 were investigated.The effects of reaction conditions on reaction results such as molar ratio,reaction temperature and reaction time were examined.The optimum conditions are as follows: nEMIM](BF4)∶n(benzoyl chloride)∶n(pyrrole) = 1.0∶1.0∶1.2,reaction temperature 50℃ and reaction time 8 h.Under these conditions the yield of 2-benzoylpyrrole was over 86%,and its purity was up to 99% by HPLC analysis.The ionic liquid can be duplicatedly used and the production rate can still reach 80% after using five times,The process can carry out without solvent. |
| Keywords: | [EMIM]BF4 ionic liquids 2-benzoylpyrrole catalysis synthesis |
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