| 壳聚糖固定化月桂酸及其吸附LDL性能研究 |
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| 引用本文： | 杜龙兵,丛海霞,方波,赵辉,陈晶晶.壳聚糖固定化月桂酸及其吸附LDL性能研究[J].化学世界,2009,50(5). |
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| 作者姓名： | 杜龙兵 丛海霞 方波 赵辉 陈晶晶 |
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| 作者单位： | 华东理工大学化学工程研究所,上海,200237 |
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| 摘 要： | 以月桂酸为原料,将其固定到活化壳聚糖上,制备一种低密度脂蛋白胆固醇(LDL-C)选择性吸附剂。考察了吸附时间、吸附剂用量对血浆LDL-C吸附效果的影响。体外间歇吸附结果表明,LDL-C的吸附率达到58.5%,对血浆总胆固醇(TC)吸附率达到35.1%,而对高密度脂蛋白胆固醇(HDL-C)的吸附率为11.4%,具有良好的选择吸附低密度脂蛋白胆固醇性能。
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| 关 键 词： | 低密度脂蛋白胆固醇吸附剂 壳聚糖 月桂酸 |
Study on Chitosan Immobilized with Lauric Acid and Its Adsorption of LDL |
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| DU Long-bing,CONG Hai-xia,FANG Bo,ZHAO Hui,CHEN Jing-jing.Study on Chitosan Immobilized with Lauric Acid and Its Adsorption of LDL[J].Chemical World,2009,50(5). |
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| Authors: | DU Long-bing CONG Hai-xia FANG Bo ZHAO Hui CHEN Jing-jing |
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| Affiliation: | Research Center of Chemical Engineering in East China University of Sci.& Tech.;Shanghai 200237;China |
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| Abstract: | A low-density lipoprotein-cholesterol(LDL-C) adsorbent was synthesized with lauric acid and chitosan.The effects of the time of adsorption,the amount of adsorbent on the LDL-C adsorption from plasma were investigated.The results of adsorption in vitro showed that the adsorption rate for total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were 35.1%,58.5% and 11.4%,respectively.The adsorbent possessed good selectivity for removing LDL-C. |
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| Keywords: | low-density lipoprotein cholesterol adsorbent chitosan lauric acid |
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