| L-丙氨酸乙酯还原反应的研究 |
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| 引用本文： | 闫喜龙,郭文琳,李阳,白国义,李乐平,陈立功.L-丙氨酸乙酯还原反应的研究[J].化学反应工程与工艺,2005,21(2):186-190. |
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| 作者姓名： | 闫喜龙 郭文琳 李阳 白国义 李乐平 陈立功 |
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| 作者单位： | 天津大学化工学院,天津,300072 |
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| 摘 要： | 对L-丙氨酸乙酯的还原方法进行了研究．采用的还原剂有NaBH4，KBH4，KBH4复合还原剂，金属钠，BER树脂，铜铬氧化物．骨架镍等。NaBH4的还原效果优于KBH4。考察了NaBH4还原L-丙氨酸乙酯的影响因素，优化最佳工艺条件为n(NaBH4)：n(L-丙氨酸乙酯)投料比2：1，用水作溶剂，室温下反应4h，收率为84．7％。添加ZnCl2，AlCl3和LiCl能提高KBH4还原活性，其中ZnCl2的效果较好，收率可达60.2％。
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| 关 键 词： | L-丙氨酸乙酯 还原反应 L-丙氨酸 （S）-2-氨基丙醇 手性氨基醇类化合物 |
| 文章编号： | 1001-7631(2005)02-0186-05 |
| 修稿时间： | 2004年11月10 |
Study on the Reduction of Ethyl L-Alaninate |
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| Yan Xilong,Guo Wenlin,Li Yang,Bai Guoyi,Li Leping,Chen Ligong.Study on the Reduction of Ethyl L-Alaninate[J].Chemical Reaction Engineering and Technology,2005,21(2):186-190. |
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| Authors: | Yan Xilong Guo Wenlin Li Yang Bai Guoyi Li Leping Chen Ligong |
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| Abstract: | By reducer including NaBH4, KBH4, sodium, BER resin, modified KBH4, copper chromic oxide, Raney Ni, reduction of ethyl L-alaninate was studied. It was found that reduction yield of NaBH4 was better than KBH4 under reaction conditions n(NaBH4) : n (Ethyl L-Alaninate) 2 : 1, water as solvent for 4h at room temperature, yield 84. 7%. The reduction activity of KBH4 increased by adding ZnCl2, A1C13 and LiCl, in which that of adding ZnCl2 was better in reduction yield of 60. 2%. |
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| Keywords: | ethyl L-alaninate reduction L-alanine (S)-2-amino-l-propanol |
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