| 2-氯-5-硝基嘧啶的合成 |
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| 引用本文： | 贾云宏,谢洪磊,蔡东,张丽华.2-氯-5-硝基嘧啶的合成[J].农药,2011,50(9). |
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| 作者姓名： | 贾云宏 谢洪磊 蔡东 张丽华 |
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| 作者单位： | 1. 辽宁医学院药学院,辽宁锦州,121001
2. 东昌府中医院,山东聊城,252000 |
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| 摘 要： | 方法]以1,1,3,3-四甲氧基丙烷和尿素为起始原料,通过合环、硝化和氯代反应得到2-氯-5-硝基嘧啶,探讨了合成关键中间体的影响因素.结果]经过实验确定了理想的反应条件,产物的结构经过1H NMR鉴定进行表征.结论]该工艺具有收率高、操作简单、安全可靠的特点并且为工业化生产提供参考.
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| 关 键 词： | 尿素 2-氯-5-硝基嘧啶 合成 |
Synthesis of 2-Chloro-5-nitropyrimidine |
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| JIA Yun-hong
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XIE Hong-lei
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CAI Dong
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ZHANG Li-hua.Synthesis of 2-Chloro-5-nitropyrimidine[J].Pesticides,2011,50(9). |
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| Authors: | JIA Yun-hong XIE Hong-lei CAI Dong ZHANG Li-hua |
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| Affiliation: | JIA Yun-hong1,XIE Hong-lei1,CAI Dong1,ZHANG Li-hua2 (1.College of Pharmacy,Liaoning Medical University,Jinzhou 121001,Liaoning,China,2.DongChang Hospital of Chinese Medicine,Liaocheng 252000,Shandong,China) |
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| Abstract: | Methods] 1,1,3,3-tetramethoxypropane and urea were used as starting material to give the 2-chloro-5-nitropyrimidine by cyclization,nitration and chlorination.The effect factors synthesizing the key intermediate were discussed.Results] The ideal conditions were determined by experiments,and their structures were confirmed by 1H NMR.Conclusions] The synthetic process has advantages of high yield,simple operation and safety and is important directive to industrialized production. |
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| Keywords: | urea 2-chloro-5-nitropyrimidine synthetic |
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