| 2,6-二氯-4-甲基三氟苯胺的合成 |
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| 引用本文： | 严中杰,任旭康,杜晓华,徐振元.2,6-二氯-4-甲基三氟苯胺的合成[J].农药,2008,47(3):174-175,178. |
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| 作者姓名： | 严中杰 任旭康 杜晓华 徐振元 |
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| 作者单位： | 浙江工业大学,催化加氢研究中心,绿色化学合成技术国家重点实验室培育基地,杭州,310014 |
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| 摘 要： | 以4-三氟甲基苯胺为原料,经H2O2/HCl体系氯化得2,6-二氯-4-三氟甲基苯胺;考察了温度、反应时间、投料比对产物收率的影响,并研究了母液的套用情况.结果表明,在80℃下,反应2h,控制双氧水和对三氟甲基苯胺的摩尔投料比为4.0～5.0时,收率达到98.4%,母液经5次套用,收率维持在95%以上.
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| 关 键 词： | 4-三氟甲基苯胺 双氧水 盐酸 |
| 文章编号： | 1006-0416（2008）03-0174-02 |
| 收稿时间： | 2007-11-23 |
| 修稿时间： | 2008-01-25 |
Process for the Preparation of 2,6-Dichloro-4-trifluoromethylaniline |
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| YAN Zhong-jie,REN Xu-kang,DU Xiao-hua,XU Zhen-yuan.Process for the Preparation of 2,6-Dichloro-4-trifluoromethylaniline[J].Pesticides,2008,47(3):174-175,178. |
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| Authors: | YAN Zhong-jie REN Xu-kang DU Xiao-hua XU Zhen-yuan |
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| Abstract: | 2,6-Dichloro-4-trifluoromethylaniline was synthesized by chlorinating 4-trifluoro- methylaniline, using H2O2/HCI as chlorinating agent. The effects of the reaction temperature, reaction period and the molar ratio of hydrogen peroxide to 4-trifluoromethylaniline were investigated. The reuse of the mother liquid was also researched. Under 80 o C for 2 hours, with a 4.0-5.0 molar ratio of hydrogen peroxide to 4-trifluoromethylaniline, the optimized yield of 98.4% was obtained. The yields were more than 95% while the mother liquid was reused for 5 times. |
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| Keywords: | 4-trifluoromethylani line hydrogen peroxide hydrochloric acid |
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