近年来吡虫啉合成新进展

叙述了2000年以来2-氯-5-氯甲基吡啶和吡虫啉的多种合成方法.2-氯-5-氯甲基吡啶的合成采用环戊二烯环合法,需研发有利于环境的绿色生产工艺,减少三废,治理三废.以3-甲基吡啶为原料一步氯化成2-氯-5-氯甲基吡啶的工艺应进一步改进.吡虫啉合成中用五氧化二磷脱水法和过量2-硝基亚氨基咪唑烷法收率接近90%.纯度达95%以上,是较佳的合成方法.

The New Improvement of Imidacloprid Synthesize in Recent Years

The synthesis methods of 2-chloro-5-chlormethylpyridine and imidacloprid from 2 000 were reviewed.The process of preparation for 2-chloro-5-chlormethylpyridine by cyclopentadiene cyclization needs to do more research by using green process and decreasing the wastes.The process of 2-chloro-5-chlormethylpyridine from 3-methylpyridine in one-step chlorination should be further improved.During the process of imidacloprid preparation,using phosphorus pentachloride dehydration and greatly excess 2-nitroiminoimida...