Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures |
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Authors: | Kyle J Sommers Brian S Bentley Dr Robert G Carden Savannah J Post Ryan A Allen Renee C Kontos Jacob W Black Prof William M Wuest Prof Kevin P C Minbiole |
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Affiliation: | 1. Department of Chemistry, Villanova University, Villanova, PA 19085 USA;2. Department of Chemistry, Emory University, Atlanta, GA 30322 USA |
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Abstract: | Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs. |
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Keywords: | antiseptics benzalkonium chloride bisQAC ferrocene methicillin-resistant Staphylococcus aureus (MRSA) quaternary ammonium compounds |
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