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“Click Peptide“: pH‐Triggered in Situ Production and Aggregation of Monomer Aβ1–42 |
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| Authors: | Atsuhiko Taniguchi Youhei Sohma Dr Yuta Hirayama Hidehito Mukai Dr Tooru Kimura Dr Yoshio Hayashi? Prof Dr Katsumi Matsuzaki Prof Dr Yoshiaki Kiso Prof Dr |
| Affiliation: | 1. Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina‐ku, Kyoto 607‐8412 (Japan), Fax: (+81)?75‐591‐9900;2. Present address: Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637 (USA);3. Present address: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192‐0392 (Japan);4. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo‐ku, Kyoto 606‐8501 (Japan) |
| Abstract: | Into neutral : We demonstrate the unique features of a pH click peptide based on an O‐acyl isopeptide method. Under acidic conditions, the click peptide remains in a monomeric form. Upon increase of the pH to 7.4, the click peptide is quickly able to convert into Aβ1–42 through an O‐to‐N intramolecular acyl migration. Further study using this pH click peptide would elucidate the pathological role of Aβ1–42 in Alzheimer's disease.  |
| Keywords: | acyl migration aggregation amyloid beta peptides click peptides isopeptide rearrangement |