The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition |
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| Authors: | Aleksandra Kaliszewska Joseph Allison Matteo Martini Natalia Arias |
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| Affiliation: | 1.Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Denmark Hill, London SE5 8AF, UK; (A.K.); (J.A.);2.Department of Psychology, University of East London, London E154LZ, UK;3.Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33005 Oviedo, Spain |
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| Abstract: | Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet. |
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| Keywords: | aging cognitive impairment diet neuroinflammation stress |
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