The Role of LGR4 (GPR48) in Normal and Cancer Processes |
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| Authors: | Alejandro Ordaz-Ramos Victor Hugo Rosales-Gallegos Jorge Melendez-Zajgla Vilma Maldonado Karla Vazquez-Santillan |
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| Affiliation: | 1.Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico; (A.O.-R.); (V.H.R.-G.);2.Epigenectics Laboratory, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico;3.Functional Genomics Laboratory, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico; |
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| Abstract: | Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor that belongs to the superfamily of G protein-coupled receptors that can be activated by R-spondins (RSPOs), Norrin, circLGR4, and the ligand of the receptor activator of nuclear factor kappa-B (RANKL) ligands to regulate signaling pathways in normal and pathological processes. LGR4 is widely expressed in different tissues where it has multiple functions such as tissue development and maintenance. LGR4 mainly acts through the Wnt/β-catenin pathway to regulate proliferation, survival, and differentiation. In cancer, LGR4 participates in tumor progression, invasion, and metastasis. Furthermore, recent evidence reveals that LGR4 is essential for the regulation of the cancer stem cell population by controlling self-renewal and regulating stem cell properties. This review summarizes the function of LGR4 and its ligands in normal and malignant processes. |
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| Keywords: | LGR4 GPR48 cancer CSCs |
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