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Osteosarcoma Pathogenesis Leads the Way to New Target Treatments |
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| Authors: | Isabel Fernandes Cecília Melo-Alvim Raquel Lopes-Brs Miguel Esperana-Martins Luís Costa |
| Affiliation: | 1.Medical Oncology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, 1600 Lisbon, Portugal; (C.M.-A.); (R.L.-B.); (M.E.-M.); (L.C.);2.Luís Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1600 Lisbon, Portugal;3.Sérgio Dias Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1600 Lisbon, Portugal |
| Abstract: | Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets. |
| Keywords: | molecular targets osteosarcoma pathogenesis |