The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review |
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| Authors: | Xuanbin Wang Longchao Xiang Hongliang Li Ping Chen Yibin Feng Jingxuan Zhang Nian Yang Fei Li Ye Wang Quifang Zhang Fang Li Fengjun Cao |
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| Affiliation: | 1.Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China; E-Mails: (L.X.); (H.L.); (P.C.); (J.Z.); (N.Y.); (Fei L.); (Y.W.); (Q.Z.); (Fang L.); (F.C.);2.Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China;3.School of Chinese Medicine, the University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China; E-Mail: |
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| Abstract: | The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study. |
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| Keywords: | high mobility group protein B1 receptor for advanced glycation end product toll-like receptor triggering receptor expressed on myeloid cells-1 hepatocellular carcinoma |
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