FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective |
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| Authors: | Patrizia Pignataro Manuela Dicarlo Roberta Zerlotin Chiara Zecca Maria Teresa Dell&#x;Abate Cinzia Buccoliero Giancarlo Logroscino Silvia Colucci Maria Grano |
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| Affiliation: | 1.Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy; (P.P.); (M.D.); (G.L.); (S.C.);2.Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy; (R.Z.); (C.B.);3.Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari, “Pia Fondazione Card G. Panico” Hospital Tricase, 73039 Lecce, Italy; (C.Z.); (M.T.D.) |
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| Abstract: | Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5 (FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) control during exercise. In addition to several beneficial effects on health, physical activity positively affects nervous system functioning, particularly the hippocampus, resulting in amelioration of cognition impairments. Recently, FNDC5/irisin detection in hippocampal neurons and the presence of irisin in the cerebrospinal fluid opened a new intriguing chapter in irisin history. Interestingly, in the hippocampus of mice, exercise increases FNDC5 levels and upregulates brain-derived neurotrophic factor (BDNF) expression. BDNF, displaying neuroprotection and anti-inflammatory effects, is mainly produced by microglia and astrocytes. In this review, we discuss how these glial cells can morphologically and functionally switch during neuroinflammation by modulating the expression of a plethora of neuroprotective or neurotoxic factors. We also focus on studies investigating the irisin role in neurodegenerative diseases (ND). The emerging involvement of irisin as a mediator of the multiple positive effects of exercise on the brain needs further studies to better deepen this issue and the potential use in therapeutic approaches for neuroinflammation and ND. |
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| Keywords: | irisin FNDC5 neuroinflammation neurodegeneration |
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