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pH-sensitive nanogels based on Boltorn H40 and poly(vinylpyridine) using mini-emulsion polymerization for delivery of hydrophobic anticancer drugs
Authors:Hamid Sadeghi Abandansari  Mohammad Reza Nabid  Seyed Jamal Tabatabaei Rezaei  Hassan Niknejad
Affiliation:1. Faculty of Chemistry, Department of Polymer, Shahid Beheshti University, G. C., 1983963113 Tehran, Iran;2. Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran;3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:In this study, we describe the synthesis of a new structure of pH-sensitive H40 based nanogel by click reaction through mini-emulsion polymerization. The nanogels were synthesized by cross coupling of H40-poly(ε-caprolactone) (H40-PCL) dendrimers as cores and poly(vinylpyridine) (PVP) as a pH sensitive crosslinker. The poly(ethylene glycol) (PEG) pendant group was introduced at the middle of PVP chains as hydrophilic segment to act as hydrophilic shell at final nanogel for better dispersity. Folic acid that is conjugated at the end of some of PEG through the free carboxyl group was used for targeting cancer cells that overexpress folate receptors.
Keywords:Boltorn®   H40  pH-sensitive nanogel  Hydrophobic drugs
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