| 单抗导向药物3A1-Dextran-DM对白血病CEM细胞特异性杀伤效应的观察 |
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| 引用本文： | 林学颜,石磊.单抗导向药物3A1-Dextran-DM对白血病CEM细胞特异性杀伤效应的观察[J].粉末涂料与涂装,1992(4). |
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| 作者姓名： | 林学颜 石磊 |
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| 作者单位： | 中山医科大学，卫生部武汉生物制品研究所 广州 510089 |
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| 摘 要： | 抗T淋巴母细胞单克隆抗体与柔红霉素的结合物,在体外对T淋巴母细胞CEM显示出选择性杀伤作用,而对K562、Raji、SP2/0等非T淋巴细胞则无杀伤效应。由此证实单抗3Al-柔红霉素免疫结合物具有导向杀伤癌细胞的性能,为临床特异性治疗肿瘤带来了新的希望。
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| 关 键 词： | 导向药物 生物导弹 单抗免疫结合物 |
The Specific Killing Effect of McAb 3A_1-Dextran-DM Immunoconjugate on the CEM Cells of Leukemia |
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| Lin Xueyan et al Sun Yat-sen University of Medical Sciences,Guangzhou.The Specific Killing Effect of McAb 3A_1-Dextran-DM Immunoconjugate on the CEM Cells of Leukemia[J].Chinese Journal of Biologicals,1992(4). |
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| Authors: | Lin Xueyan Sun Yat-sen University of Medical Sciences Guangzhou |
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| Abstract: | The immunoconjugation of anti-T lymphoblast monoclonal antibody and daunomycin (DM) could selectively kill T lymphoblast CEM in vitro and did not show any effect on the non-T lymphocytes, such as K562, Raji and SP2/0, et al. The result suggested that McAb 3A1-DM immunoconjugate could be regarded as a promising effective agent in the specific treatment for cancer. |
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| Keywords: | McAb 3Al McAb immunoconjugate 3Al-Dextran-DM |
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