| 无催化剂条件下微波合成2-羟基苯并咪唑 |
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| 引用本文： | 常慧,宁满侠,刘传生,赵鸿斌.无催化剂条件下微波合成2-羟基苯并咪唑[J].精细化工中间体,2007,37(5):29-30. |
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| 作者姓名： | 常慧 宁满侠 刘传生 赵鸿斌 |
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| 作者单位： | 1. 东莞理工学院,化学生物工程系,广东,东莞,523808
2. 东莞理工学院,化学生物工程系,广东,东莞,523808;湘潭大学,化学学院,湖南,湘潭,411105 |
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| 摘 要： | 在无催化剂条件下,利用邻苯二胺与尿素的熔融缩合反应,微波辐射合成了2-羟基苯并咪唑,即苯并咪唑酮。合成无需溶剂和催化剂,反应速度快,操作简便、安全,过程节能、环保。对影响合成收率的条件因素进行了考察。结果表明:微波输出功率为638W、间歇辐射时间9min、n(邻苯二胺)∶n(尿素)=1∶1时,收率可达88.4%,产品经红外光谱确认。
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| 关 键 词： | 微波辐射 2-羟基苯并咪唑(苯并咪唑酮) 合成 |
| 文章编号： | 1009-9212（2007）05-0029-02 |
| 修稿时间： | 2007-07-09 |
Synthesis of 2-Hydroxybenzimidazole under Microwave Irradiation without Catalysis |
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| CHANG Hui,NING Man-xia,LIU Chuan-Sheng,ZHAO Hong-bin.Synthesis of 2-Hydroxybenzimidazole under Microwave Irradiation without Catalysis[J].Fine Chemical Intermediates,2007,37(5):29-30. |
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| Authors: | CHANG Hui NING Man-xia LIU Chuan-Sheng ZHAO Hong-bin |
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| Affiliation: | 1.Faculty of Chemical Bioteehnology, Dongguan University of Technology, Dongguan 523808, China; 2.College of Chemistry, Xiangtan University, Xiangtan 411105, China |
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| Abstract: | 2-Hydrxybenzimidazole was synthesized via the condensation reaction of o-phenylenediamine and urea under microwave irradiation without catalysis condition. The methods had a characteristic of fast reaction,simple operation,safety,low energy consumptions and environmental protection. The optimum conditions were as follow:microwave power 638 W,microwave irradiation time 9 min,the mole ratio of o-phenylendiamin and urea 1∶1.1. Under the above conditions,the yield was 88.4%. The product was identified by IR. |
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| Keywords: | microwave irradiation 2-hydroxybenzimidazole(benzimidazolone ) synthesis |
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