| N,N-二乙基-3,7-二甲基-(Z)-2,6-辛二烯-1-胺的合成研究 |
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| 引用本文： | 杨阳,尤亚华,姚日生.N,N-二乙基-3,7-二甲基-(Z)-2,6-辛二烯-1-胺的合成研究[J].精细化工中间体,2012,42(2):41-43,63. |
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| 作者姓名： | 杨阳 尤亚华 姚日生 |
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| 作者单位： | 1. 合肥工业大学 化学工程学院,安徽合肥,230009
2. 合肥工业大学医学工程学院,安徽合肥230009;农产品生物化工教育部重点实验室生物化工与制药工程研究所,合肥安徽230009 |
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| 摘 要： | 以异戊二烯(IP)和二乙胺(DEA)为原料,在正丁基锂催化下合成了N,N-二乙基-3,7-二甲基-(Z)-2,6-辛二烯-1-胺(NDEA)。利用气谱分析NDEA,考察了不同因素对合成NDEA的影响,确定了较优的工艺条件:原料配比n(IP)∶n(DEA)=4.5∶1.0,n(n-BuLi)∶n(IP)=2∶3,反应温度为环己烷的回流温度,反应时间为13 h。产品收率>55%(n/n),经减压分馏后产品纯度>97%。
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| 关 键 词： | 合成香料 异戊二烯 N N-二乙基-3 7-二甲基-(Z)-2 6-辛二烯-1-胺 |
A Study on Synthesis of N,N-Diethyl-3,7-dimethyl- (Z) -octadien-1 -amine |
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| YANG Yang
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YOU Ya-hua
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YAO Ri-sheng.A Study on Synthesis of N,N-Diethyl-3,7-dimethyl- (Z) -octadien-1 -amine[J].Fine Chemical Intermediates,2012,42(2):41-43,63. |
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| Authors: | YANG Yang YOU Ya-hua YAO Ri-sheng |
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| Affiliation: | 2,3(1.School of Chemical Engineering,Hefei University of Technology,Hefei 230009,China;2.School of Medical Engineering,Hefei University of Technology,Hefei 230009,China;3.Engineering Research Center of Bioprocess of Ministry of Education,Hefei 230009,China) |
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| Abstract: | N,N-Diethylnerylamine(NDEA),an important intermediate for organic synthesis,was prepared from isoprene and diethylamine catalyzed by n-BuLi in cyclohexane.The mechanism of the reaction was discussed,and NDEA was analyzed with GC.The effects of different factors on the reaction were studied.The optimum reaction conditions were as follows:the molar ratio of IP to DEA 4.5 to 1,of IP to n-BuLi 2∶3,reaction time 13 h,in refluxed cyclohexane.NDEA was resulted in 55% yield with a purity of 97% after fractional distillation. |
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| Keywords: | synthetic perfume isoprene N N-diethylnerylamine |
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