| 右雷佐生的合成 |
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| 引用本文： | 余彩霞,杨艺虹,张珩,杨建设.右雷佐生的合成[J].精细化工中间体,2010,40(4):38-40. |
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| 作者姓名： | 余彩霞 杨艺虹 张珩 杨建设 |
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| 作者单位： | 武汉工程大学,化工与制药学院,绿色化工过程省部共建教育部重点实验室,湖北,武汉,430073 |
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| 摘 要： | 以(±)-1,2-丙二胺为起始原料,D-(-)-酒石酸为拆分剂,经拆分得(S)-1,2-丙二胺二酒石酸盐;再与氯化钾反应得(S)-1,2-丙二胺二盐酸盐;然后在氢氧化钠催化下与氯乙酸缩合制备(S)-N,N,N',N'-1,2-丙二胺四乙酸;最后与甲酰胺环合制得心脏保护剂右雷佐生。总收率为35.7%,其结构经1H NMR和IR确证。
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| 关 键 词： | 右雷佐生 S-1 2-丙二胺 拆分 合成 |
Synthesis of Dexrazoxane |
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| YU Cai-xia,YANG Yi-hong,ZHANG Heng,YANG Jian-she.Synthesis of Dexrazoxane[J].Fine Chemical Intermediates,2010,40(4):38-40. |
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| Authors: | YU Cai-xia YANG Yi-hong ZHANG Heng YANG Jian-she |
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| Affiliation: | (Key Laboratory for Green Chemical Process of Ministry of Education,Wuhan Institute of Technology,Wuhan 430073,China) |
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| Abstract: | Dexrazoxane,a cardiac medicine,was synthesized in 35.7% overall yield starting from racemic 1,2-diaminopropane.The resolution of 1,2-diaminopropane with D-（-）-tartaric acid followed by reaction with potassium chloride resulted in（S）-1,2-diaminopropane dihydrochloride,which was further converted into the title compound in two steps.The structure was confirmed with 1H NMR and IR. |
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| Keywords: | dexrazoxane S-1 2-diaminopropane resolution synthesis |
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