| (R)-(-)-α-甲氧基苯乙酸的2种合成方法 |
| |
| 引用本文： | 沈思思,王吕鸣,孙金涛,沙宇.(R)-(-)-α-甲氧基苯乙酸的2种合成方法[J].精细化工中间体,2013(2):37-38,41. |
| |
| 作者姓名： | 沈思思 王吕鸣 孙金涛 沙宇 |
| |
| 作者单位： | 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室 |
| |
| 基金项目： | 辽宁省教育厅资助项目(2009226015-5) |
| |
| 摘 要： | (R)-(-)-α-甲氧基苯乙酸的2种合成方法均是以简单易得的扁桃酸为原料,经醚化,或者经酯化醚化、水解得单一构型(R)-(-)-α-甲氧基苯乙酸,其结构经MS、1H NMR、13C NMR分析确证。产品纯度99.3%(HPLC),反应收率52.0%。路线一方法与原有文献相比,后处理操作简单、耗时短、收率高,而路线二方法是无文献报道的全新方法。2种方法均利于工业化生产。
|
| 关 键 词： | (R)-(-)-α-甲氧基苯乙酸 扁桃酸 醚化 酯化 水解 |
Two Synthetic Methods of （R）-2-Methoxy-2-phenylacetic Acid |
| |
| SHEN Si-si,WANG Lü-ming,SUN Jin-tao,SHA Yu.Two Synthetic Methods of （R）-2-Methoxy-2-phenylacetic Acid[J].Fine Chemical Intermediates,2013(2):37-38,41. |
| |
| Authors: | SHEN Si-si WANG Lü-ming SUN Jin-tao SHA Yu |
| |
| Affiliation: | (Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China) |
| |
| Abstract: | （R）-2-Methoxy-2-phenylacetic acid was synthesized from mandelic acid via esterification etherification and hydrolysis,or via only a single step of etherification.Its structure was confirmed by MS,1H NMR and13C NMR.The purity of the product was 99.3%（HPLC）,and overall yield was 52.0%.The former method shows the advantages of convenient operation,time saving and high yield,whereas the latter is a novel way never reported.These two methods are both suitable for industrial process. |
| |
| Keywords: | （R）-2-methoxy-2-phenylacetic acid mandelic acid etherification esterification hydrolysis |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
