Dietary fatty acids early in life affect lipid metabolism and adiposity in young rats |
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Authors: | Ana Paula S Silva Daniella E D Guimarães Daniella M Mizurini Ingrid C Maia Susana Ortiz-Costa Fátima L Sardinha Maria G Tavares do Carmo |
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Affiliation: | 1. Instituto de Nutri??o Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 2o andar, 21.941-590, Rio de Janeiro, Brazil
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Abstract: | The purpose of this study was to evaluate the effects of four isoenergetic diets of differing fat composition on blood lipid
profile and adiposity in young rats. Diets containing different lipid sources—partially hydrogenated vegetable oil (PHVO),
palm oil (PO), canola oil (CO), and soy oil (SO)—were fed to lactating rats during the 21 days of lactation, and then fed
to young males following weaning until the 45th, day of life. In vivo lipogenesis rate (LR), lipid content (LC), relative level of FA, and the activity of lipoprotein lipase (LPL) enzyme were
measured in epididymal adipose tissue (EPI). Fasting blood lipoproteins and LC in the carcass were also appraised. Body weight
of PO and PHVO groups was significantly higher than CO and SO groups from day 14 of lactation to day 45, despite the lower
food intake in the PHVO group. PO and PHVO groups presented higher LR and LC in EPI than SO and CO groups. Carcass fat content
was significantly higher in PHVO and PO groups than in CO and SO groups. The LPL activity in EPI was unaffected by dietary
lipids. PHVO group had increased total cholesterol and TAG concentrations in comparison with the PO group, and significantly
lower HDL level compared with the other groups. These results show that the kind of FA in the dietary lipid offered early
in life can affect lipid metabolism and adiposity. |
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