| Pd(PPh3)4催化Suzuki偶联反应合成4-溴-2-氟-联苯 |
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| 引用本文： | 高丰琴,何汉江.Pd(PPh3)4催化Suzuki偶联反应合成4-溴-2-氟-联苯[J].精细化工,2012,29(11):1142-1144. |
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| 作者姓名： | 高丰琴 何汉江 |
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| 作者单位： | 陕西咸阳师范学院化学系,西安瑞联近代电子材料有限责任公司 |
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| 摘 要： | 以苯硼酸和2-氟-4-溴碘苯为起始原料,经Suzuki偶联反应合成了色谱纯度99.5%以上的医药和液晶中间体4-溴-2-氟-联苯,目标化合物进行了1HNMR、IR和GC-MS表征。结果表明,反应体系中氧气的存在是导致硼酸自偶副产物产生的主要原因;Pd(PPh3)4催化剂及过量的苯硼酸均会导致三联苯副产物的产生。
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| 关 键 词： | Suzuki偶联反应 4-溴-2-氟-联苯 催化 精细化工中间体 |
| 收稿时间： | 2012/7/26 0:00:00 |
| 修稿时间： | 2012/8/29 0:00:00 |
Synthesis of 4-bromo-2-fluorobiphenyl by SuzukiCoupling Reaction with Pd(PPh3)4 Catalysis |
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| Gao Feng-qin and He Han-jiang.Synthesis of 4-bromo-2-fluorobiphenyl by SuzukiCoupling Reaction with Pd(PPh3)4 Catalysis[J].Fine Chemicals,2012,29(11):1142-1144. |
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| Authors: | Gao Feng-qin and He Han-jiang |
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| Affiliation: | 1.Xianyang Normal University,Xianyang 712000,Shaanxi,China;2.Xi′an Ruilian Modern Electronic Materials Co.,Ltd.,Xi′an 710075,Shaanxi,China) |
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| Abstract: | The medicine and liquid crystal intermediate 4-bromo-2-fluorobiphenyl of a purity of 99.5% was synthesized via Suzuki coupling reaction with phenyl boric acid and 2-fluoro-4-bromo-iodobenzene as starting materials.The target compound was characterized by means of 1HNMR,IR and GC-MS.The results of condition experiments show that the existence of oxygen in the reaction system was the major generation reason of the by-product of boric acid self-coupling;the catalyst Pd(PPh3)4 and the excessive dosage of phenyl boric acid both resulted in the generation of the by-product terphenyl. |
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| Keywords: | Suzuki coupling reaction 4-bromo-2-fluorobiphenyl catalysis fine chemical intermediates |
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