| 2-氟-4-(反式-4-烷基环己基)苯基硼酸的合成 |
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| 引用本文： | 李娟利,安忠维.2-氟-4-(反式-4-烷基环己基)苯基硼酸的合成[J].精细化工,2006,23(3):310-312. |
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| 作者姓名： | 李娟利 安忠维 |
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| 作者单位： | 西安近代化学研究所,光电材料中心,陕西,西安,710065 |
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| 摘 要： | 以1-(反式-4-烷基环己基)-3-氟苯与丁基锂、硼酸三丁酯、叔丁醇钾为反应物合成了2-氟-4-(反式-4-烷基环己基)苯基硼酸化合物3个,总收率为52%~56%,分别用IR,1HNMR对其结构进行了鉴定。优化了反应条件:n1-(反式-4-烷基环己基)-3-氟苯]∶n(叔丁醇钾)∶n(丁基锂)∶n(硼酸三丁酯)=1∶2∶1.2∶1.5,反应温度-85~-90℃,反应时间2.5 h。叔丁醇钾的加入使反应时间由7 h缩短至2.5 h。
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| 关 键 词： | 丁基锂 硼酸三丁酯 叔丁醇钾 2-氟-4-(反式-4-烷基环己基)苯基硼酸 |
| 文章编号： | 1003-5214（2006）03-0310-03 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-09-122005-11-04 |
Synthesis of 2-Fluoro-4-( trans-4-alkylcyclohexyl)phenylboronic Acid |
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| LI Juan-li,AN Zhong-wei.Synthesis of 2-Fluoro-4-( trans-4-alkylcyclohexyl)phenylboronic Acid[J].Fine Chemicals,2006,23(3):310-312. |
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| Authors: | LI Juan-li AN Zhong-wei |
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| Abstract: | Three compounds of 2-fluoro-4-(trans-4-alkylcyclohexyl)phenylboronic acid were synthesized using 1-(trans-4-alkylcyclohexyl)-3-fluorobenzene,n-butyllithium,tributyl borate,and potassium tert-butoxide as reactants,their yields were 52%～56%,and their structures were confirmed by IR and ~1HNMR.The reaction conditions were optimized:n1-(trans-4-alkylcyclohexyl)-3-fluorobenzene]∶n(potassium tert-butoxide)∶n(n-butyllithium)∶n(tributyl borate)=1∶2∶1.2∶1.5,reaction temperature-85～-90 ℃ and reaction time 2.5 h.The addition of potassium tert-butoxide shortened the reaction time from 7 h to 2.5 h. |
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| Keywords: | n-butyllithium tributyl borate potassium tertbutoxide 2-fluoro-4-(trans-4-alkylcyclohexyl)phenylboronic acid |
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