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| TCDCANa的合成及抗菌抗炎作用研究 | |
| 引用本文： | 公瑞煜,张立冬,何佳奇,张熹,金云龙,李建蓉,乔学亮.TCDCANa的合成及抗菌抗炎作用研究[J].精细化工,2007,24(11):1087-1090. |
| 作者姓名： | 公瑞煜 张立冬 何佳奇 张熹 金云龙 李建蓉 乔学亮 |
| 作者单位： | 1. 华中科技大学,同济医学院药学院,湖北,武汉,430030 2. 杭州民生药业集团有限公司,浙江,杭州,310011 3. 华中科技大学,同济医学院基础医学院,湖北,武汉,430030 4. 华中科技大学,材料学院,湖北,武汉,430074 |
| 基金项目： | 国家自然科学基金 , 华中科技大学校科研和教改项目 , 华中科技大学校科研和教改项目 |
| 摘 要： | 以鹅去氧胆酸(CDCA)和牛磺酸为基本原料合成了牛磺鹅去氧胆酸钠(TCDCANa),以萃取和重结晶法提纯,收率63.4%,w(TCDCANa)≥92%,以TLC和IR法确定了其结构。并将牛磺鹅去氧胆酸钠与鹅去氧胆酸钠(CDCANa)进行了抗菌、抗炎和镇咳对比实验。药效实验结果为:TCDCANa和CDCANa均具有抗革兰阳性菌作用(抑菌环直径分别为2.46±0.08cm和1.91±0.13cm),抗炎作用抑制率分别为(79.1±25.4)%和(71.2±23.1)%,镇咳作用减咳率分别为(29.1±5.6)%和(18.2±6.8)%,牛磺鹅去氧胆酸钠与鹅去氧胆酸钠间存在显著性差异。药效实验表明,TCDCANa具明显的镇咳、平喘和抗菌作用,其作用强于CDCANa。 |
| 关 键 词： | 牛磺鹅去氧胆酸 抗菌 抗炎 中药现代化 |
| 文章编号： | 1003-5214（2007）11-1087-04 |
| 修稿时间： | 2007-03-24 |
Preparation and Antibacterial and Anti-inflammatory Effects of TCDCANa |
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| GONG Rui-yu,ZHANG Li-dong,HE Jia-qi,ZHANG Xi,JIN Yun-long,LI Jian-rong,QIAO Xue-liang.Preparation and Antibacterial and Anti-inflammatory Effects of TCDCANa[J].Fine Chemicals,2007,24(11):1087-1090. | |
| Authors: | GONG Rui-yu ZHANG Li-dong HE Jia-qi ZHANG Xi JIN Yun-long LI Jian-rong QIAO Xue-liang |
| Affiliation: | 1. Pharmaceutical School of Tongji Medical College, Huazhong University of Seience and Technology, Wuhan 430030, Hubei , China ;2. Hangzhou Minsheng Pharmaceutical Group Co. , Ltd , Hangzhou 310011 , Zhejiang , China;3. Department of Pathogenic Biology of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Habei, China ;4. Department of Material Science and Engineering, Huazhong University of Science and Technology, Wahan 430074,Hubei, China |
| Abstract: | The sodium taurochenodeoxycholate(TCDCANa) was prepared by conjugating starting compound chenodeoxycholic acid with taurine,and purified by means of extraction and recrystallization.The yield of TCDCANa was 63.4% and purity w(TCDCANa)≥92%.Its structure was confirmed by TLC and IR.Antibacterial test,anti-inflammatory test and antitussive test were made.With TCDCANa and sodium chenodeoxycholate(CDCANa),the results of pharmacodynamics are respectively:diameter of bacterial inhibition zone (2.46±0.08) and (1.91±0.13) cm,rate of inhibition (79.1±25.4)% and (71.2±23.1)%,and antitussive rate (29.1±5.6)% and(18.2±6.8)%.There are significant differences in all those data between TCDCANa and CDCANa (P<0.01).It is proved that TCDCANa has more evident antibacterial,anti-inflammatory and antitussive effects than CDCANa. |
| Keywords: | taurochenodeoxycholic acid antibacterial anti-inflammatory modernization of Chinese medicine |
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