响应面法优化微胶囊复合壁材配比

采用高压静电微胶囊制备装置,以成囊合格率为检测指标,选择海藻酸钠等为壁材,运用Box-Behnken中心组合设计和响应面分析,研究了壁材配比对微胶囊特性的影响。得到的最优条件是:壁材组成为质量分数1.53%(以下都是质量分数)海藻酸钠,4.52%聚乙烯醇,1%明胶,1%甘油,成囊溶液氯化钙质量浓度为22.86g/L,微胶囊合格率为87.37%。在最优条件下制备出的微胶囊内外表面光滑,囊壁透明,分散性好,形态完整。可为食品、医药、化工等微胶囊化壁材配比选择提供参考。

Optimization of the Composite Wall Material of Microcapsule by Response Surface Methodology

The characteristics of microcapsule are mostly determined by the wall material which is an important part of it.Using the high-voltage electrostatic microcapsule forming device,the effect of the mass ratio of wall material on the characteristics of microcapsule was investigated based on the Box-Behnken central composite design and response surface analysis,with the qualified rate chosen as indicator,and with the wall material being sodium alginate etc.The main factors which affect the microcapsule were regression modeling and optimization.The optimal conditions were ascertained as follows:the wall material was made up of 1.53% sodium alginate,4.52% PVA,1% gelatin content,and 1% glycerol,with the encysted solution being 22.86 g/L CaCl2.Under such optimal conditions,the qualified rate of microcapsule was 87.37%.The microcapsules prepared under such conditions have many merits,such as smooth inner and outer surface,transparence,good dispersity,and complete morphology.This optimized wall material ratio could provide reference for making microcapsules in such industries as food,medicine,chemical engineering,and so on.