细胞固定化催化生产精细化学品的研究进展Q

摘要：细胞固定化技术具有流程简单、生物相容、操作稳定等优点，可有效保证细胞活性，实现高效的细胞催化生产精细化学品。本文介绍了表面附着、凝胶包埋、聚电解质层层自组装膜等多细胞固定化方法，及其在二元醇、生物乙醇、乳酸、酯、多糖等精细化学品生产中的研究现状和进展，并分析讨论了各种方法存在的问题。同时，总结了近年来新发展的单细胞纳米涂层固定化方法的机理、趋势及应用于精细化学品生产的可能性。最后对细胞固定化催化生产精细化学品面临的技术挑战及研究方向做出展望，以期为精细化学品生产提供一定的技术支持。

Progress of cell immobilization catalysis in fine chemicals production

Abstract: Cell immobilization technology has the advantages of simple process, biocompatibility, stable operation, etc., which can effectively ensure cell viability and realize efficient cell-catalyzed production of fine chemicals. The research status and progress of traditional multi-cell immobilization methods such as surface attachment, gel embedding, and polyelectrolyte layer-by-layer self-assembled membranes in the field of fine chemical (e.g. dihydric alcohols, bioethanol, lactic acid, ester, polysaccharide) production are mainly introduced, followed with the problem analysis. Then, the mechanism, and trend of a new developing immobilization method, single-cell nano-coating, are summarized with the possible application for fine chemicals production. Finally, the technical challenges and research directions that cell immobilization technology faces in the production of fine chemicals are prospected, with a purpose to providing certain technical support for the production of fine chemicals.