| 2-(1-H-四唑)-4’-甲基联苯的合成 |
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| 引用本文： | 汪家宏,沈叶楠,龙中柱,张程亮,王巧纯. 2-(1-H-四唑)-4’-甲基联苯的合成[J]. 精细化工, 2015, 32(5) |
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| 作者姓名： | 汪家宏 沈叶楠 龙中柱 张程亮 王巧纯 |
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| 作者单位： | 1. 华东理工大学 精细化工研究所 结构可控先进功能材料及其制备教育部重点实验室,上海,200237
2. 启东东岳药业有限公司,江苏启东,226200 |
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| 基金项目： | 江苏省企业院士工作站（项目编号：BM2013038） |
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| 摘 要： | 以2-氰基-4'-甲基联苯(Ⅱ)为原料,与氨基钠反应得到2-脒基-4'-甲基联苯(Ⅲ),该化合物与水合肼发生取代反应得到4'-甲基-[1,1'-联苯]-2-甲酰胺酰肼(Ⅳ),最后在酸性条件下与亚硝酸钠发生闭环反应得到2-(1-H-四唑)-4'-甲基联苯(Ⅰ),总收率达到81%,其结构经1HNMR和MS确证。
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| 关 键 词： | 2-(1-H-四唑)-4'-甲基联苯 沙坦联苯 四氮唑 精细化工中间体 |
| 收稿时间： | 2014-12-22 |
| 修稿时间： | 2015-02-15 |
Synthesis of 5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole |
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| wangjiahong,shenyenan,longzhongzhu,zhangchengliang and wangqiaochun. Synthesis of 5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole[J]. Fine Chemicals, 2015, 32(5) |
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| Authors: | wangjiahong shenyenan longzhongzhu zhangchengliang wangqiaochun |
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| Affiliation: | East China University of Science and Technology,East China University of Science and Technology,Qidong dongyue Pharm. Co., Ltd,Qidong dongyue Pharm. Co., Ltd.,East China University of Science and Technology |
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| Abstract: | 5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole was synthesized from 4'-methyl-[1,1'-biphenyl]-2-carbonitrile as the starting material in a total yield of 81%. 4'-Methyl-[1,1'-biphenyl]-2-carboximidamide(3) was firstly obtained by the addition of 4'-methyl-[1,1'-biphenyl]-2-carbonitrile with sodium amide in toluene. The consequent substitution reaction of 3 with hydrazine hydrate resulted in the formation of 4'-methyl-[1,1'-biphenyl]-2-carboximidhydrazide(4), and the final acidic cyclization of 4 with sodium nitrite gave the title compound 5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole(1), whose structure was characterized by 1H NMR and MS. |
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| Keywords: | 5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 2-cyano-4'-methylbiphenyl tetrazole fine chemical intermediates |
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