| 铝催化7-氯-6-氟-1,4-二氢-4-氧喹啉-3-羧酸乙酯的合成 |
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| 引用本文： | 杨家强.铝催化7-氯-6-氟-1,4-二氢-4-氧喹啉-3-羧酸乙酯的合成[J].精细化工,2012,29(4):403-405. |
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| 作者姓名： | 杨家强 |
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| 作者单位： | 1. 遵义医学院药学院,贵州遵义,563003
2. 贵州大学精细化工研究中心,贵州贵阳,550025 |
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| 摘 要： | 以Al为催化剂,在微波辐射条件下,由3-氯-4-氟苯胺基甲叉丙二酸二乙酯环合制备标题化合物。通过优化实验得到最佳反应条件为:微波功率160 W、反应温度80℃、反应时间20 min,在该条件下目标物产率达94.2%。对产物进行了熔点、NMR测定,确定为目标产物。
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| 关 键 词： | Al 微波合成 喹啉羧酸酯 精细化工中间体 |
| 收稿时间： | 2011/12/26 0:00:00 |
| 修稿时间： | 2012/1/14 0:00:00 |
Synthesis of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate catalyzed by aluminium metal |
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| YANG Jia-qiang.Synthesis of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate catalyzed by aluminium metal[J].Fine Chemicals,2012,29(4):403-405. |
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| Authors: | YANG Jia-qiang |
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| Affiliation: | 1.School of Pharmacy,Zunyi Medical College,Zunyi 563003,Guizhou,China;2.Center for Research and Development of Fine Chemicals,Guizhou University,Guiyang 550025,Guizhou,China) |
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| Abstract: | Ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate was synthesized by Gould-Jacobs reaction under microwave-assistance using aluminium metal as catalyst.The optimum reaction conditions were ascertained by experiment program as follows:the microwave power was 160 W,the reaction temperature was 80 ℃,and the reaction time was 20 min,with Al being used as catalyst.The overall product yield was 94.2%.The structure of the product was determined by melting point measurements and NMR spectrometry that were applied to verify the target product. |
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| Keywords: | aluminium metal microwave-assisted synthesis quinoline carboxlic acid ester |
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