| 2,3,4-三甲氧基-6-甲基苯酚的合成 |
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| 引用本文： | 杨运泉,王威燕,揭嘉,陈田,童刚生.2,3,4-三甲氧基-6-甲基苯酚的合成[J].精细化工,2008,25(9). |
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| 作者姓名： | 杨运泉 王威燕 揭嘉 陈田 童刚生 |
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| 作者单位： | 湘潭大学,化工学院,湖南,湘潭,411105 |
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| 基金项目： | 湖南省科技厅科技攻关项目 |
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| 摘 要： | 以3,4,5-三甲氧基甲苯为原料,采用Vilsmeier-Haack和Dakin两步反应合成了2,3,4-三甲氧基-6-甲基苯酚,并对Dakin反应中的各影响因素进行了优化。实验确定的最佳反应条件是:在对甲基苯磺酸的催化下,n(6-甲基-2,3,4-三甲氧基苯甲醛)∶n(双氧水)=0.83∶1,以0.1 mL/min速率缓慢滴加w(H2O2)=30%的双氧水,25℃反应2 h。在此条件下Dakin反应收率为96.2%,过程总收率达90.5%。
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| 关 键 词： | 辅酶Q0 Vilsmeier-Haack反应 Dakin反应 2 3 4-三甲氧基-6-甲基苯酚 |
Synthesis of 2,3,4-Trimethoxy-6-methylphenol |
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| YANG Yun-quan,WANG Wei-yan,JIE Jia,CHEN Tian,TONG Gang-sheng.Synthesis of 2,3,4-Trimethoxy-6-methylphenol[J].Fine Chemicals,2008,25(9). |
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| Authors: | YANG Yun-quan WANG Wei-yan JIE Jia CHEN Tian TONG Gang-sheng |
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| Abstract: | 2,3,4-Trimethoxy-6-methylphenol was synthesized from 3,4,5-trimethoxytoluene through Vilsmeier-Haack reaction and Dakin reaction.The optimal conditions of Dakin reaction were n(6-methyl-2,3,4-trimethoxy-benzaldehycle)∶n(H2O2)=0.83∶1,p-toluenesulfonic acid as catalyst,reaction temperature 25 ℃,reaction time 2 h and w(H2O2)=30% in trickling rate of 0.1 mL/min.Under the optimal conditions,a yield of 96.2% was obtained.The two-step yield was 90.5%. |
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| Keywords: | Coenzyme Q0 Vilsmeier-Haack reaction Dakin reaction 2 3 4-trimethoxy-6-methylphenol |
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