Temperature and pH sensitive hydrogels composed of chitosan and poly(ethylene glycol) |
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Authors: | Jagjit R Khurma Ashveen V Nand |
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Affiliation: | (1) Division of Chemistry, Faculty of Science and Technology, University of the South Pacific, Suva, Fiji Islands |
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Abstract: | Summary Chitosan based semi-interpenetrating polymer network (semi-IPN) hydrogels containing different amounts of poly(ethylene glycol)
(PEG) were prepared. The crosslinking of the hydrogels was achieved by using a naturally occurring nontoxic cross-linking
agent genipin. The swelling behaviour of these hydrogels was studied by immersing the films in deionized water at 25, 37 and
45 °C and in media of different pHs at 37 °C. Swelling was found to be dependent on temperature, pH of the medium and the
amount of PEG in the gel. States of water in the hydrogels swollen in deionized water at 37 °C were determined using Differential
Scanning Calorimetry (DSC). The equilibrium water content and the amount of freezing water in the swollen hydrogels increased
with the increase in PEG concentration in the gels. |
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Keywords: | Chitosan Poly(ethylene glycol) Hydrogels Genipin Swelling behaviour States of water |
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