| 替马沙星中间体7-氯-6-氟-1-(2,4-二氟苯基)-1,4-二氢-4-氧-3-喹啉羧酸合成方法的改进 |
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| 引用本文： | 戴立言,陈英奇,吴兆立.替马沙星中间体7-氯-6-氟-1-(2,4-二氟苯基)-1,4-二氢-4-氧-3-喹啉羧酸合成方法的改进[J].高校化学工程学报,2001,15(5):468-471. |
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| 作者姓名： | 戴立言 陈英奇 吴兆立 |
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| 作者单位： | 浙江大学材料与化工学院, |
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| 摘 要： | 以2，4－二氯－5－氟苯甲酰基乙酸甲酸乙酯为原料，经乙氧亚甲基化、二氟苯胺胺化、环合、水解和脱羰反应对替马沙星中间体7－氯－6－氟－1－（2，4－二氟苯基）－1，4－二氢－4－氧－3－喹啉羧酸的合成方法了改进；反应条件温和，操作容易控制。并在此过程中合成了三种新的中间体化合物4，5和6。
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| 关 键 词： | 替马沙星 合成 中间体 抗菌药物 7－氯－6－氟－1－（2 4－二氟苯基）－1 4－二氢－4－氧－3－喹啉羧酸 |
| 文章编号： | 1003-9015(2001)05-0468-04 |
| 修稿时间： | 2000年2月22日 |
Improved Synthetic Method for Temafloxacin's Intermediate 7-chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid |
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| DAI Li-yan,CHEN Ying-qi,WU Zhao-li.Improved Synthetic Method for Temafloxacin's Intermediate 7-chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid[J].Journal of Chemical Engineering of Chinese Universities,2001,15(5):468-471. |
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| Authors: | DAI Li-yan CHEN Ying-qi WU Zhao-li |
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| Abstract: | The research present an improved synthetic method of 7-chloro-6-fluoro-1-(2,4-difluorophenyl) -1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, the important intermediate of temafloxacin. The reaction was started with 2,4-dichloro-5-fluorobenzoyl acetoformic ethyl ester, via amination, cyclization, hydrolysis and decarbonylation. The reaction temperature was moderate and the operation was easily controlled. Moreover, three new intermediates 4,5 and 6 were synthesized by the suggested method. |
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| Keywords: | temafloxacin synthesis intermediate |
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