噻虫嗪的合成技术 |
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引用本文: | 陆阳,陶京朝,周志莲.噻虫嗪的合成技术[J].化工中间体,2010,6(1):20-24. |
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作者姓名: | 陆阳 陶京朝 周志莲 |
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作者单位: | 1. 信阳农专有机化学教研室,河南,信阳,464000 2. 郑州大学化学系,河南,郑州,450001 3. 河南科易集团新药研究开发中心,河南,信阳,464000 |
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摘 要: | 以2,3-二氯丙烯和硫氰酸钠为起始原料,首先生成中间体2-氯丙烯硫代异氰酸酯(1),(1)再与苄基硫醇加成,环合生成中间体2-苄硫基-5-氯甲基噻唑(2);(2)与3-甲基-4-硝基亚胺-1,3,5-恶二嗪反应生成中间体苄硫基噻虫嗪(3);(3)与氯气反应生成目标化合物噻虫嗪,合成总收率达到50.6%。研究了噻虫嗪的合成工艺,分析并实验优化了主要的合成工艺参数。该合成路线原料易得,反应过程稳定,收率高,产品质量好,有利于工业化生产。
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关 键 词: | 2 3-二氯丙烯 苄基硫醇 噻虫嗪 合成 |
Synthesis of Thiamethoxam |
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Authors: | Lu Yang Tao Jingzhao Zhang Zhirong |
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Affiliation: | Lu Yang1 Tao Jingzhao2 Zhang Zhirong (1.Office of Organic chemistry,Xinyang Agriculture College,Xinyang 464000 Henan Province,China,2.Chemistry Department of ZhengZhou University,ZhengZhou 450001,3.New Drug Research , DebelopmentCenterHenan KeYi Group,Xinyang 464000 Henan) |
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Abstract: | Using propylene 2,3-dichloride and sodium cyanide sulfur as raw material,combine intermiate 2-chloride propylene sulfide isocyanate (1);(1)through addition with benzylic thiol,cyclization to prepare intermediate 2-benzylic thiolation-5-chloromethyl thiazole (2);(2)combinewith3-methyl-4-nitro-aminous-1.3.5-oxadiazine to produce thiolation thiamethoxam (3); thiamethoxam was synthesized from (3) and chlorine. The total yield was 50.6%. The influence of reaction was investigated detailedly in molar ratio,temper... |
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Keywords: | propylene 2 3-dichloride benzylic thiol thiamethoxam synthesis |
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