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Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity |
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| Authors: | Charles E Carraher Jr Theodore S Sabir Michael R Roner Kimberely Shahi Robert E Bleicher Joanne L Roehr Kelly D Bassett |
| Affiliation: | (1) Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA;(2) Department of Chemistry, Providence Christian College, Ontario, CA 91761, USA;(3) Department of Biology, University of Texas at Arlington, Arlington, TX 76010, USA;(4) California State University Channel Islands, Camarillo, CA 93012, USA;(5) Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA |
| Abstract: | Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles. |
| Keywords: | Organotin polymers acyclovir interfacial polymerization MALDI-TOF MS herpes chicken pox small pox shingles reovirus ST3 HSV-1 viruses viruses bioterrorism VZV virus varicella zoster virus vaccinia WR virus herpes simplex virus anticancer drugs L929 cells 143 cells BS-C-1 cells vero cells |
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