阳离子交换树脂法制备L-组氨酸钙工艺

采用阳离子交换树脂法制备L-组氨酸螯合钙，测定了D151和110两种弱酸型阳离子交换树脂的钙离子交换容量及其在26℃下的交换动力学曲线，并考察了温度、NaOH与L-组氨酸摩尔比、L-组氨酸初始浓度和树脂量对2种树脂钙交换过程的影响. 结果表明，D151和110的钙交换容量分别为1.12和2.59 mmol/g；交换过程迅速，工业上交换0.5 h即可达到平衡；钙离子交换是一个放热过程，工业生产中可在室温下或低温下进行；适宜的NaOH与L-组氨酸摩尔比为(1~1.25):1；用D151树脂时适宜的L-组氨酸初始浓度和树脂量分别约为0.46 mol/L和0.125 g/mL；用110树脂时分别约为0.4 mol/L和0.15 g/mL.

Preparation of Complex of L-Histidine Calcium with Cation Exchange Resin

The complex of L-histidine calcium was prepared with D151 and 110 cation exchange resins. The calcium exchange capacities and exchange kinetic curves at 26℃ with the resins were measured. And the effects of temperature, molar ratio of NaOH to L-histidine, concentration of L-histidine, and quantity of resin on calcium exchange process were determined. The results show that calcium exchange capacities of D151 and 110 resins were 1.12 and 2.59 mmol/g, the exchange process was quick, and calcium exchange process exothermic, so industrial process could be carried out at room temperature or low temperature. The proper molar ratio of NaOH to L-histidine was (1～1.25):1, the proper concentration and resin quantity of D151 cation exchange resin were 0.46 mol/L and 0.125 g/mL or so, and those of 110 resin were 0.4 mol/L and 0.15 g/mL or so.