| 几种新的吡唑啉衍生物的合成 |
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| 引用本文： | 刘谦,李晓,赵梦婕,张健.几种新的吡唑啉衍生物的合成[J].广州化工,2014(3):37-39. |
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| 作者姓名： | 刘谦 李晓 赵梦婕 张健 |
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| 作者单位： | 中南民族大学化学与材料学院,湖北武汉430074 |
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| 摘 要： | 以水杨醛、乙酰乙酸乙酯为原料合成3-乙酰基香豆素,3-乙酰基香豆素与各种取代基的苯甲醛反应生成相应的查尔酮,查尔酮再与2-肼基苯并噻唑反应合成了5种未见报道的吡唑啉,并通过核磁氢谱等对吡唑啉进行了表征。并对合成吡唑啉条件中的溶剂的选择以及温度的单因素实验,对合成条件进行了优化。
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| 关 键 词： | -乙酰基香豆素 查尔酮 合成 吡唑啉 |
The Synthesis of Several New Pyrazolines |
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| Affiliation: | LIU Qian, LI Xiao, ZHAO Meng -fie, ZttANG Jian ( College of Chemistry and Materials Science, South - Central University for Nationalities, HuBei Wuhan 430074, China) |
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| Abstract: | With salicylic aldehyde and ethyl acetoacetate as raw material, 3 - acetylcoumarin was synthesized. Using 3 - acetylcoumarin reacted with few of arylaldehydes, different chalcones were prepared, and 2 - hydrazinobenzothiazole was made from 2 - aminobenzothiazol, finally five pyrazolines which had not been reported were got. All of the novel compounds were confirmed by ^1H NMR. Through the selecting of solvent and temperature of single factor experiment, optimum reaction conditions were obtained from the experiment. |
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| Keywords: | 3 - acetylcoumarin chalcone synthesis Dvrazoline |
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