| 3-氨基吡唑-4-甲酰胺半硫酸盐的合成 |
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| 引用本文： | 陈绘如,肖国民,陈闻起,丁敬敏,张文雯.3-氨基吡唑-4-甲酰胺半硫酸盐的合成[J].化工时刊,2008,22(6):39-40. |
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| 作者姓名： | 陈绘如 肖国民 陈闻起 丁敬敏 张文雯 |
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| 作者单位： | 1. 常州工程职业技术学院,应化系,江苏常州,213164
2. 东南大学化学化工系,江苏南京,211189 |
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| 摘 要： | 以原甲酸三乙酯、丙二腈为起始原料，合成乙氧亚甲基丙二腈，将其加入80％水合肼中，加热回流1h，生成3-氨基-4-甲酰胺吡唑，将其与浓硫酸混和，调节pH值，40℃下搅拌0．5h，经过滤，重结晶，得到目标化合物3-氨基吡唑-4-甲酰胺半硫酸盐，总收率63．7％（以丙二腈计）。目标化合物结构经红外光谱、核磁共振分析验证。
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| 关 键 词： | 3-氨基吡唑-4-甲酰胺半硫酸盐 合成 别嘌醇 |
Synthesis of 3-amino-4-pyrazolecarboxamide Hemisulfate |
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| Chen Huiru,Xiao Guomin,Chen Wenqi,Ding Jingmin,Zhang Wenwen.Synthesis of 3-amino-4-pyrazolecarboxamide Hemisulfate[J].Chemical Industry Times,2008,22(6):39-40. |
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| Authors: | Chen Huiru Xiao Guomin Chen Wenqi Ding Jingmin Zhang Wenwen |
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| Affiliation: | Chen Huiru Xiao Guomin Chen Wenqi Ding Jingmin Zhang Wenwen ( Department of Applied Chemistry Technology, Changzhou Institute of Engineering Technology, Jiangsu Changzhou 213164, China; 2 Department of Chemistry ＆ Chemical Engineering, Southeast University, Jiangsu Nanjing 210096) |
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| Abstract: | Malononitril was treated with ethyl orthoformate to give intermediate ethoxymethylenemalononitrile, which was added in 80% hydrazine hydrate and the mixture was stirred at reflux temperature for 1 h to afford 3 - amino -4 - pyrazolecarboxamide. Then the compound was mixed with sulfuric acid and stirred at 40℃ for 0.5h. By filtration and recrystallization, the title compound 3 -amino -4 -pyrazolecarboxamide hemisulfate was obtained. Total yield of this procedure reached to 63.7%. The product was confirmed by means of IR and 1HNMR. |
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| Keywords: | 3 - amino - 4 - pyrazolecarboxamide hemisulfate synthesis allopurinol |
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