烷基磷酸酯与共轭亚油酸形成杂化囊泡的研究

脂肪酸囊泡(FAV)的中空壳核结构能够包埋活性分子。为改善FAV仅在其p Ka附近形成的缺陷,以拓宽FAV的应用范围,将安全性和温和性阴离子表面活性剂烷基磷酸酯钾盐(MAPK)添加到共轭亚油酸中,通过动态激光光散射(DLS)和透射电子显微镜(TEM)研究了囊泡化的pH窗口,发现9%MAPK存在时就可以在中性至酸性环境中形成杂化FAV,不明显改变原有FAV的形貌及粒径,且随着MAPK添加量的增大,杂化FAV的pH窗口有逐渐拓宽的趋势。这一结果显示了杂化FAV在化妆品和个人卫生护理用品等领域的应用前景。

Study on formation of hybrid vesicles with alkyl phosphate and conjugated linoleic acid

Fatty acid vesicles (FAVs) with a hollow core-shell structure can entrap reactive molecules. In order to improve the defect that FAVs can form near its pKa only so as to enlarge their application field, mild anionic surfactant potassium alkyl phosphate (MAPK) was added to conjugated linoleic acid (CLA). The pH window for vesicles formation was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). It was found that hybrid FAVs can be formed at neutral to acidic environment by blending CLA with 9% MAPK without significant change of morphology and particle size of the original FAVs, and the pH window of the hybrid FAVs has a tendency to gradually broaden along with increasing of the dosage of MAPK. The result shows the potential application of FAVs in fields of cosmetics and personal health care products.