萘哌地尔合成工艺的改进

改进了萘哌地尔的合成工艺条件：投料比n（3-（1-萘氧基）-1,2-环氧丙烷）∶n（邻甲氧基哌嗪氢溴酸盐）∶n（K2CO3）=1.01∶1∶1.5,以氯仿-水的非均相溶液为反应溶剂,在回流温度（60~63℃）反应5h制得萘哌地尔粗品;再以丙酮-水（4∶1）为溶剂,精制得到高纯度的成品（纯度≥99%）。该工艺条件温和,操作简便,产品质量稳定可靠,两步总收率达到72.3%。

Improved Synthesis of Eapidil

This article introduced the process conditions of improved synthetic process for Eapidil:the mole ratio was 3-(1-naphthyloxy)-1,2-propylene oxide∶o-methoxypiperazine∶Potassium carbonate=1.01 ∶ 1.0 ∶ 1.5,solvent:mixture of chloroform and water,reaction temperature:60～63℃,and reaction time:5h.Refine the final product via the mixture solvent of acetone and water(4 ∶ 1).The purity of Eapidil was not less than 99% with 72.3% overall yield.This process conditions were not severe and has simplified operation and high quality product.