| N-取代苄基-N’-苯甲酰氧乙基哌嗪类化合物的合成及其生物活性 |
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| 引用本文： | 韩生华,陈建新,孟双明,马鹏飞.N-取代苄基-N’-苯甲酰氧乙基哌嗪类化合物的合成及其生物活性[J].化学与生物工程,2013,30(5):38-41. |
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| 作者姓名： | 韩生华 陈建新 孟双明 马鹏飞 |
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| 作者单位： | 1. 山西大同大学化学与化工学院,山西大同,037009
2. 山西师范大学化学与材料学院,山西临汾,041004 |
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| 基金项目： | 山西省自然科学基金资助项目 |
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| 摘 要： | 合成了15个新的N-取代苄基-N’-苯甲酰氧乙基哌嗪类化合物，其结构经红外光谱、核磁共振氢谱、元素分析及质谱确证，平初步测定了目标化合物的生物活性。结果表明，目标化合物均表现出一定的对血清诱导的血管平滑肌细胞增殖的抑制活性，其中化合物ⅣC、Ⅳd、Ⅳh活性较高。
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| 关 键 词： | 哌嗪 合成 血管平滑肌细胞 抑制活性 |
Synthesis and Bioactivity of N-(Substituted)benzyl-N'-benzoyloxy-ethyl Piperazine Derivatives |
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| HAN Sheng-hua
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CHEN Jian-xin
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MENG Shuang-ming
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MA Peng-fei.Synthesis and Bioactivity of N-(Substituted)benzyl-N'-benzoyloxy-ethyl Piperazine Derivatives[J].Chemistry & Bioengineering,2013,30(5):38-41. |
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| Authors: | HAN Sheng-hua CHEN Jian-xin MENG Shuang-ming MA Peng-fei |
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| Affiliation: | 1(1.School of Chemistry and Chemical Engineering,Shanxi Datong University,Datong037009,China;2.School of Chemistry and Materials,Shanxi Normal University,Linfen041004,China) |
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| Abstract: | Fifteen new N-（substituted）benzyl-N＇-benzoyloxy-ethyl piperazine derivatives were synthesized, and their structures were confirmed by IR,1HNMR, elemental analysis and MS. Their inhibitory activities a- gainst vascular smooth muscle cells proliferation induced by FBS were evaluated. All the object compounds showed inhibitory activity to a certain extent on vascular smooth muscle cells proliferation, especially com- poundsⅣ c, Ⅳ d and Ⅳ h. |
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| Keywords: | piperazine synthesis vascular smooth muscle cells inhibitory activity |
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