| 盐酸羟嗪合成的研究新进展 |
| |
| 引用本文： | 钟敏,彭小海,罗瑾,尤庆亮,喻宗沅.盐酸羟嗪合成的研究新进展[J].化学与生物工程,2011,28(8):1-4. |
| |
| 作者姓名： | 钟敏 彭小海 罗瑾 尤庆亮 喻宗沅 |
| |
| 作者单位： | 湖北省化学研究院,湖北武汉,430074 |
| |
| 摘 要： | 总结了第一代抗组胺药盐酸羟嗪及其重要中间体2-(2-氯乙氧基)乙醇和母环1-(4-氯苯基)苯甲基]-哌嗪的各种合成路线,并对各路线进行了评述,选出了一条适合工业化的路线:由1-(4-氯苯基)苯甲基]-哌嗪与2-(2-氯乙氧基)乙醇缩合,酸化,制得盐酸羟嗪.
|
| 关 键 词： | 抗组胺 盐酸羟嗪 2-(2-氯乙氧基)乙醇 1-[(4-氯苯基)苯甲基]-哌嗪 合成 |
Recent Research Progress on Synthesis of Hydroxyzine Dihydrochloride |
| |
| ZHONG Min,PENG Xiao-hai,LUO Jin,YOU Qing-liang,YU Zong-yuan.Recent Research Progress on Synthesis of Hydroxyzine Dihydrochloride[J].Chemistry & Bioengineering,2011,28(8):1-4. |
| |
| Authors: | ZHONG Min PENG Xiao-hai LUO Jin YOU Qing-liang YU Zong-yuan |
| |
| Affiliation: | ZHONG Min,PENG Xiao-hai,LUO Jin,YOU Qing-liang,YU Zong-yuan(Hubei Research Institute of Chemistry,Wuhan 430074,China) |
| |
| Abstract: | Various synthetic routes of the first generation antihistamines hydroxyzine dihydrochloride,its key intermediate 2-(2-chloroethoxy) ethanol and the main ring 1-(4-chlorophenyl)benzyl]-piperazine were summarized and commented.A suitable route for industrialization was selected as follows:hydroxyzine dihydrochloride was obtained through condensation of 2-(2-chloroethoxy) ethanol and 1-(4-chlorophenyl)benzyl]-piperazine,acidification. |
| |
| Keywords: | antihistamines hydroxyzine dihydrochloride 2-(2-chloroethoxy) ethanol 1-[(4-chlorophenyl)-benzyl]-piperazine synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
