| 改进Skraup法制备8-羟基喹啉的研究 |
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| 引用本文： | 刘端,李翔,刘小成,何嘉俊,刘昱.改进Skraup法制备8-羟基喹啉的研究[J].化学与生物工程,2009,26(8):43-44,47. |
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| 作者姓名： | 刘端 李翔 刘小成 何嘉俊 刘昱 |
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| 作者单位： | 湖北省化学研究院,湖北,武汉,430074 |
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| 摘 要： | 采用改进的Skraup法,以丙烯醛代替甘油,以邻氨基苯酚、邻硝基苯酚、丙烯醛为原料在盐酸、醋酸存在的条件下合成了8-羟基喹啉.通过正交实验探讨了丙烯醛滴加时间、醋酸用量、丙烯醛用量、邻硝基苯酚用量、反应时间对产率的影响.确定最佳反应条件为:邻氨基苯酚用量为21.8 g(0.20 mol)、邻硝基苯酚用量为14.6 g(0.11 mol)、丙烯醛用量为20.2 g(0.36 mol)、醋酸用量为22.0 g(0.37 mol)、盐酸200 mL、丙烯醛滴加时间为3 h、加热反应时间为1.0 h.此时,8-羟基喹啉的产率达72%.
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| 关 键 词： | 8-羟基喹啉 Skraup法 丙烯醛 |
Study on Synthesis of 8-Hydroxyquinoline by Improved Skraup Method |
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| LIU Duan,LI Xiang,LIU Xiao-cheng,HE Jia-jun,LIU Yu.Study on Synthesis of 8-Hydroxyquinoline by Improved Skraup Method[J].Chemistry & Bioengineering,2009,26(8):43-44,47. |
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| Authors: | LIU Duan LI Xiang LIU Xiao-cheng HE Jia-jun LIU Yu |
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| Affiliation: | LIU Duan,LI Xiang,LIU Xiao-cheng,HE Jia-jun,LIU Yu(Hubei Research Institute of Chemistry,Wuhan 430074,China) |
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| Abstract: | By improved Skraup method with acrolein replacing glycerine,8-hydroxyquinoline is synthesized from o-aminophenol,o-nitrophenol,acrolein in the presence of acetic acid and hydrochloric acid.By orthogonal experiment,the effects of different reaction conditions on the yield have been discussed.The optimum reaction conditions are determined as follows: o-aminophenol amount is 21.8 g(0.20 mol),o-nitrophenol amount is 14.6 g(0.11 mol),acrolein amount is 20.2 g(0.36 mol),acetic acid amount is 22.0 g(0.37 mol),hydr... |
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| Keywords: | 8-hydroxyquinoline Skraup method acrolein |
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