纳米级超声造影剂的理论研究进展

为了克服超声造影剂中微米级气泡尺寸较大的局限性,大量研究人员对超声应用的替代造影剂(纳米级造影剂)进行了研究。随着生物纳米技术的飞速发展,纳米级超声造影剂在诊断与治疗领域有着广阔的发展前景。与超声造影剂中的微米级气泡相比,纳米级造影剂粒径较小,渗透能力极强,可以通过血管内皮间隙,进而可以实现血管外病变部位的显影。文中详细论述了超声造影剂在超声作用下的行为以及2种主要的纳米级造影剂:纳米气泡和纳米液滴造影剂,对其理论研究进展进行了总结,并提出了目前仍存在的一些问题及其未来的研究方向。

Advances in Theoretical Research on Nanoscale Ultrasonic Contrast Agents

In order to overcome the limitation of micrometer bubble size in ultrasonic contrast agent,a large number of researchers have studied the alternative contrast agents(nanoscale contrast agents)for ultrasonic applications.With the rapid development of bio-logical nanotechnology,nanoscale ultrasound contrast agent has a broad prospect in the field of diagnosis and treatment.Compared with micrometer bubble size in ultrasonic contrast agent,nanoscale contrast agent has small particle size and strong permeability,and can be used for extravascular development of lesion sites through vascular endothelial space and then realize extravascular imaging of lesion area outside the vessel.In this paper,the behavior of ultrasonic contrast agent under ultrasonic action and two main nanoscale contrast agents(nanobubbles and nanodroplets)are described in detail.This paper summarizes the theoretical research progress,and puts forward some existing problems and future research directions.